Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/import.php on line 29

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Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/import.php on line 32

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Strict Standards: Non-static method JRequest::clean() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/import.php on line 33

Strict Standards: Non-static method JRequest::_cleanArray() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 463

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Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/import.php on line 35

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Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/import.php on line 38

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/import.php on line 39

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/import.php on line 46

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/import.php on line 47

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/import.php on line 50

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/import.php on line 53

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/import.php on line 54

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/import.php on line 57

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/import.php on line 58

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Strict Standards: Non-static method JFactory::getApplication() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/index.php on line 31

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Strict Standards: Redefining already defined constructor for class JObject in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/base/object.php on line 57

Strict Standards: Non-static method JApplication::getInstance() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 46

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Strict Standards: Non-static method JApplicationHelper::getClientInfo() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 130

Strict Standards: Declaration of JSite::getRouter() should be compatible with & JApplication::getRouter($name = NULL, $options = Array) in /home2/sirdik/public_html/fbmi.sirdik.org/includes/application.php on line 377

Strict Standards: Declaration of JSite::getPathWay() should be compatible with & JApplication::getPathway($name = NULL, $options = Array) in /home2/sirdik/public_html/fbmi.sirdik.org/includes/application.php on line 377

Strict Standards: Declaration of JSite::getMenu() should be compatible with & JApplication::getMenu($name = NULL, $options = Array) in /home2/sirdik/public_html/fbmi.sirdik.org/includes/application.php on line 377

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Deprecated: Non-static method JFactory::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 730

Deprecated: Non-static method JFactory::_createConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 73

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/registry/registry.php on line 19

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Deprecated: Non-static method JUtility::getHash() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 99

Deprecated: Non-static method JFactory::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/utilities/utility.php on line 111

Deprecated: Non-static method JFactory::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 382

Deprecated: Non-static method JFactory::getSession() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 768

Deprecated: Non-static method JFactory::_createSession() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 94

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Deprecated: Non-static method JFactory::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 501

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Strict Standards: Declaration of JSession::set() should be compatible with JObject::set($property, $value = NULL) in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/session/session.php on line 737

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/session/session.php on line 19

Deprecated: Non-static method JSession::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 507

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Deprecated: Non-static method JSessionStorage::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/session/session.php on line 108

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Deprecated: Non-static method JFilterInput::clean() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/session/storage.php on line 57

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Warning: session_start(): Cannot send session cookie - headers already sent by (output started at /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/import.php:29) in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/session/session.php on line 423

Deprecated: Non-static method JFactory::getDBO() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/session/storage/database.php on line 64

Deprecated: Non-static method JFactory::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 268

Deprecated: Non-static method JFactory::_createDBO() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 271

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Deprecated: Non-static method JFactory::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 551

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Deprecated: Non-static method JDatabase::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 563

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Deprecated: Non-static method JError::isError() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 565

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Deprecated: Non-static method JTable::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/session/storage/database.php on line 69

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Deprecated: Non-static method JPath::find() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/database/table.php on line 91

Deprecated: Non-static method JTable::addIncludePath() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/database/table.php on line 91

Deprecated: Non-static method JFactory::getDBO() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/database/table.php on line 112

Warning: session_start(): Cannot send session cache limiter - headers already sent (output started at /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/import.php:29) in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/session/session.php on line 423

Warning: Cannot modify header information - headers already sent by (output started at /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/import.php:29) in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/session/session.php on line 426

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JTable::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 771

Deprecated: Non-static method JFactory::getDBO() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/database/table.php on line 112

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/html/parameter.php on line 21

Deprecated: Non-static method JFactory::getUser() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/application.php on line 53

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JFactory::getSession() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 163

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Deprecated: Non-static method JComponentHelper::getParams() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/application.php on line 60

Deprecated: Non-static method JComponentHelper::getComponent() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/component/helper.php on line 83

Deprecated: Non-static method JComponentHelper::_load() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/component/helper.php on line 39

Deprecated: Non-static method JFactory::getDBO() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/component/helper.php on line 196

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Deprecated: Non-static method JRegistryFormat::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/registry/registry.php on line 373

Deprecated: Non-static method JFilterInput::clean() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/registry/format.php on line 45

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Strict Standards: Declaration of JRegistryFormatINI::objectToString() should be compatible with JRegistryFormat::objectToString(&$object) in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/registry/format/ini.php on line 281

Deprecated: Non-static method JApplicationHelper::getClientInfo() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/application.php on line 61

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Deprecated: Non-static method JLanguage::exists() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/application.php on line 68

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JFolder::exists() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/language/language.php on line 265

Deprecated: Non-static method JPath::clean() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/filesystem/folder.php on line 392

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Deprecated: Non-static method JFactory::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 164

Deprecated: Non-static method JFactory::getUser() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 172

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JFactory::getSession() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 163

Deprecated: Non-static method JFactory::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 382

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Deprecated: Non-static method JPluginHelper::isEnabled() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 174

Deprecated: Non-static method JPluginHelper::getPlugin() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 75

Deprecated: Non-static method JPluginHelper::_load() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 41

Deprecated: Non-static method JFactory::getDBO() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 174

Deprecated: Non-static method JFactory::getUser() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 175

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JFactory::getSession() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 163

Strict Standards: Non-static method JPluginHelper::importPlugin() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/index.php on line 41

Strict Standards: Non-static method JPluginHelper::_load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 92

Strict Standards: Non-static method JPluginHelper::_import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 97

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Strict Standards: Redefining already defined constructor for class JPlugin in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/plugin.php on line 75

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Strict Standards: Declaration of JEvent::update() should be compatible with JObserver::update() in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/event/event.php on line 29

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Strict Standards: Non-static method JDispatcher::getInstance() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 140

Strict Standards: Non-static method JPluginHelper::getPlugin() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 147

Strict Standards: Non-static method JPluginHelper::_load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 41

Deprecated: Non-static method JPluginHelper::getPlugin() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/plugins/system/joomsef.php on line 22

Deprecated: Non-static method JPluginHelper::_load() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 41

Strict Standards: Non-static method JPluginHelper::_import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 97

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JDispatcher::getInstance() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 140

Strict Standards: Non-static method JPluginHelper::getPlugin() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 147

Strict Standards: Non-static method JPluginHelper::_load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 41

Strict Standards: Non-static method JPluginHelper::_import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 97

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JDispatcher::getInstance() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 140

Strict Standards: Non-static method JPluginHelper::getPlugin() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 147

Strict Standards: Non-static method JPluginHelper::_load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 41

Deprecated: Non-static method JRegistryFormat::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/registry/registry.php on line 373

Deprecated: Non-static method JFilterInput::clean() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/registry/format.php on line 45

Deprecated: Non-static method JFactory::getDocument() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/plugins/system/JoomSEO.php on line 52

Deprecated: Non-static method JFactory::_createDocument() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 140

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Deprecated: Non-static method JFactory::getLanguage() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 702

Deprecated: Non-static method JFactory::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 116

Deprecated: Non-static method JFactory::_createLanguage() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 119

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JFactory::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 683

Deprecated: Non-static method JLanguage::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 685

Deprecated: Non-static method JFactory::getXMLParser() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/language/language.php on line 760

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Deprecated: Non-static method JRegistryFormat::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/registry/registry.php on line 373

Deprecated: Non-static method JFilterInput::clean() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/registry/format.php on line 45

Deprecated: Non-static method JRequest::getBool() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 705

Deprecated: Non-static method JRequest::getVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 217

Deprecated: Non-static method JRequest::_cleanVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 151

Deprecated: Non-static method JFilterInput::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 577

Deprecated: Non-static method JRequest::getWord() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 706

Deprecated: Non-static method JRequest::getVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 236

Deprecated: Non-static method JRequest::_cleanVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 151

Deprecated: Non-static method JFilterInput::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 577

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/document/document.php on line 19

Deprecated: Non-static method JDocument::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 716

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Strict Standards: Declaration of JDocumentHTML::setBuffer() should be compatible with JDocument::setBuffer($content) in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/document/html/html.php on line 394

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Deprecated: Non-static method JFactory::getCache() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/plugins/system/JoomSEO.php on line 58

Deprecated: Non-static method JFactory::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 192

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/cache/cache.php on line 19

Deprecated: Non-static method JCache::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 208

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Strict Standards: Declaration of JCacheCallback::get() should be compatible with JCache::get($id, $group = NULL) in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/cache/handler/callback.php on line 133

Deprecated: Non-static method JRequest::getCmd() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/cache/cache.php on line 87

Deprecated: Non-static method JRequest::getVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 255

Deprecated: Non-static method JRequest::_cleanVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 151

Deprecated: Non-static method JFilterInput::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 577

Deprecated: Non-static method JRegistryFormat::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/registry/registry.php on line 373

Deprecated: Non-static method JFilterInput::clean() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/registry/format.php on line 45

Strict Standards: Non-static method JPluginHelper::_import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 97

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JDispatcher::getInstance() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 140

Strict Standards: Non-static method JPluginHelper::getPlugin() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 147

Strict Standards: Non-static method JPluginHelper::_load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 41

Strict Standards: Non-static method JPluginHelper::_import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 97

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JDispatcher::getInstance() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 140

Strict Standards: Non-static method JPluginHelper::getPlugin() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 147

Strict Standards: Non-static method JPluginHelper::_load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 41

Deprecated: Non-static method JRegistryFormat::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/registry/registry.php on line 373

Deprecated: Non-static method JFilterInput::clean() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/registry/format.php on line 45

Deprecated: Non-static method JFactory::getLanguage() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/plugin.php on line 113

Deprecated: Non-static method JRegistryFormat::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/registry/registry.php on line 373

Deprecated: Non-static method JFilterInput::clean() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/registry/format.php on line 45

Strict Standards: Non-static method JPluginHelper::_import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 97

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JDispatcher::getInstance() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 140

Strict Standards: Non-static method JPluginHelper::getPlugin() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 147

Strict Standards: Non-static method JPluginHelper::_load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 41

Deprecated: Non-static method JDispatcher::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 499

Deprecated: Non-static method JFactory::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/plugins/system/joomsef.php on line 34

Deprecated: Non-static method SEFConfig::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/plugins/system/joomsef.php on line 39

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Deprecated: Non-static method JHTML::addIncludePath() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/plugins/system/mtupgrade.php on line 48

Deprecated: Non-static method JPath::clean() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/html/html.php on line 326

Deprecated: Non-static method JFactory::getUser() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/plugins/system/remember.php on line 52

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JFactory::getSession() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 163

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JUtility::getHash() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/plugins/system/remember.php on line 56

Deprecated: Non-static method JFactory::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/utilities/utility.php on line 111

Deprecated: Non-static method JRequest::getString() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/plugins/system/remember.php on line 58

Deprecated: Non-static method JRequest::getVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 276

Deprecated: Non-static method JRequest::_cleanVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 151

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Deprecated: Non-static method JURI::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 192

Deprecated: Non-static method JFactory::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/application.php on line 372

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Deprecated: Non-static method JRouter::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 659

Deprecated: Non-static method JApplicationHelper::getClientInfo() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/router.php on line 98

Deprecated: Non-static method JError::isError() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 660

Deprecated: Non-static method JFactory::getApplication() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/router.php on line 40

Deprecated: Non-static method JFactory::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 382

Deprecated: Non-static method JFactory::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 382

Deprecated: Non-static method JURI::base() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/router.php on line 67

Deprecated: Non-static method JFactory::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/uri.php on line 230

Deprecated: Non-static method JURI::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/uri.php on line 240

Deprecated: Non-static method JFactory::getApplication() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/router.php on line 366

Deprecated: Non-static method JSite::getMenu() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/router.php on line 163

Deprecated: Non-static method JApplication::getMenu() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/application.php on line 345

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Deprecated: Non-static method JMenu::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 705

Deprecated: Non-static method JApplicationHelper::getClientInfo() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/menu.php on line 93

Deprecated: Non-static method JFactory::getCache() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/menu.php on line 36

Deprecated: Non-static method JFactory::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 192

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JCache::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 208

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Deprecated: Non-static method JRequest::getCmd() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/cache/cache.php on line 87

Deprecated: Non-static method JRequest::getVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 255

Deprecated: Non-static method JRequest::_cleanVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 151

Deprecated: Non-static method JFilterInput::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 577

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Strict Standards: Declaration of JCacheStorage::get() should be compatible with JObject::get($property, $default = NULL) in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/cache/storage.php on line 173

Deprecated: Non-static method JCacheStorage::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/cache/cache.php on line 313

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Deprecated: Non-static method JFactory::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/cache/storage/file.php on line 37

Deprecated: Non-static method JError::isError() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/cache/cache.php on line 206

Deprecated: Non-static method JFactory::getDBO() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/menu.php on line 40

Deprecated: Non-static method JError::isError() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/cache/cache.php on line 229

Deprecated: Non-static method JError::isError() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 706

Deprecated: Non-static method JRequest::set() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 197

Deprecated: Non-static method JRequest::setVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 423

Deprecated: Non-static method JRequest::setVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 423

Deprecated: Non-static method JRequest::setVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 423

Deprecated: Non-static method JRequest::setVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 423

Deprecated: Non-static method JRequest::setVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 423

Strict Standards: Non-static method JRequest::getInt() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/index.php on line 55

Strict Standards: Non-static method JRequest::getVar() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 179

Strict Standards: Non-static method JRequest::_cleanVar() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 134

Strict Standards: Non-static method JFilterInput::getInstance() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 577

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JMenu::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 705

Deprecated: Non-static method JError::isError() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 706

Deprecated: Non-static method JFactory::getUser() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/application.php on line 198

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JFactory::getSession() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 163

Deprecated: Non-static method JDispatcher::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 499

Deprecated: Non-static method JFactory::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/plugins/system/joomsef.php on line 62

Deprecated: Non-static method SEFConfig::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/plugins/system/joomsef.php on line 67

Strict Standards: Non-static method JRequest::getCmd() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/index.php on line 67

Strict Standards: Non-static method JRequest::getVar() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 255

Strict Standards: Non-static method JRequest::_cleanVar() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 134

Strict Standards: Non-static method JFilterInput::getInstance() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 577

Deprecated: Non-static method JFactory::getDocument() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/application.php on line 91

Deprecated: Non-static method JFactory::getUser() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/application.php on line 92

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JFactory::getSession() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 163

Deprecated: Non-static method JFactory::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/application.php on line 372

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JRouter::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 659

Deprecated: Non-static method JError::isError() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 660

Deprecated: Non-static method JRequest::getCmd() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/application.php on line 238

Deprecated: Non-static method JRequest::getVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 255

Deprecated: Non-static method JRequest::_cleanVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 134

Deprecated: Non-static method JFilterInput::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 577

Deprecated: Non-static method JComponentHelper::getParams() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/application.php on line 240

Deprecated: Non-static method JComponentHelper::getComponent() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/component/helper.php on line 83

Deprecated: Non-static method JComponentHelper::_load() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/component/helper.php on line 39

Deprecated: Non-static method JRegistryFormat::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/registry/registry.php on line 373

Deprecated: Non-static method JFilterInput::clean() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/registry/format.php on line 45

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JMenu::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 705

Deprecated: Non-static method JError::isError() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 706

Deprecated: Non-static method JFactory::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 382

Deprecated: Non-static method JFactory::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 382

Deprecated: Non-static method JRegistryFormat::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/registry/registry.php on line 373

Deprecated: Non-static method JFilterInput::clean() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/registry/format.php on line 45

Deprecated: Non-static method JFactory::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 382

Deprecated: Non-static method JURI::current() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/application.php on line 108

Deprecated: Non-static method JURI::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/uri.php on line 299

Deprecated: Non-static method JComponentHelper::renderComponent() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/application.php on line 124

Deprecated: Non-static method JComponentHelper::isEnabled() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/component/helper.php on line 119

Deprecated: Non-static method JComponentHelper::getComponent() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/component/helper.php on line 67

Deprecated: Non-static method JComponentHelper::_load() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/component/helper.php on line 39

Deprecated: Non-static method JFactory::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 382

Deprecated: Non-static method JRequest::getString() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/component/helper.php on line 151

Deprecated: Non-static method JRequest::getVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 276

Deprecated: Non-static method JRequest::_cleanVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 151

Deprecated: Non-static method JFilterInput::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 577

Deprecated: preg_replace(): The /e modifier is deprecated, use preg_replace_callback instead in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/filter/filterinput.php on line 512

Deprecated: preg_replace(): The /e modifier is deprecated, use preg_replace_callback instead in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/filter/filterinput.php on line 514

Deprecated: Non-static method JFactory::getLanguage() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/component/helper.php on line 154

Deprecated: Non-static method JRegistryFormat::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/registry/registry.php on line 373

Deprecated: Non-static method JFilterInput::clean() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/registry/format.php on line 45
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Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Strict Standards: Declaration of ContentController::display() should be compatible with JController::display($cachable = false) in /home2/sirdik/public_html/fbmi.sirdik.org/components/com_content/controller.php on line 28

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Deprecated: Non-static method JModel::addIncludePath() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/component/controller.php on line 382

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JPath::clean() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/component/model.php on line 253

Deprecated: Non-static method JRequest::getVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/components/com_content/content.php on line 35

Deprecated: Non-static method JHTML::_() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/components/com_content/controller.php on line 37

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JPath::find() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/html/html.php on line 66

Deprecated: Non-static method JHTML::addIncludePath() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/html/html.php on line 66

Strict Standards: call_user_func_array() expects parameter 1 to be a valid callback, non-static method JHTMLBehavior::caption() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/html/html.php on line 91

Strict Standards: Non-static method JHTML::script() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/plugins/system/mtupgrade/behavior.php on line 86

Strict Standards: Non-static method JHTML::_() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/html/html.php on line 172

Strict Standards: call_user_func_array() expects parameter 1 to be a valid callback, non-static method JHTMLBehavior::mootools() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/html/html.php on line 91

Strict Standards: Non-static method JFactory::getConfig() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/plugins/system/mtupgrade/behavior.php on line 52

Strict Standards: Non-static method JHTML::script() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/plugins/system/mtupgrade/behavior.php on line 66

Strict Standards: Non-static method JURI::root() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/html/html.php on line 176

Strict Standards: Non-static method JURI::base() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/uri.php on line 272

Strict Standards: Non-static method JURI::getInstance() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/uri.php on line 272

Strict Standards: Non-static method JFactory::getDocument() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/html/html.php on line 179

Strict Standards: Non-static method JFactory::getApplication() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/plugins/system/mtupgrade/behavior.php on line 70

Strict Standards: Non-static method JURI::root() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/html/html.php on line 176

Strict Standards: Non-static method JFactory::getDocument() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/html/html.php on line 179

Deprecated: Non-static method JRequest::getCmd() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/components/com_content/controller.php on line 40

Deprecated: Non-static method JRequest::getVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 255

Deprecated: Non-static method JRequest::_cleanVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 134

Deprecated: Non-static method JFilterInput::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 577

Deprecated: Non-static method JFactory::getUser() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/components/com_content/controller.php on line 46

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JFactory::getSession() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 163

Deprecated: Non-static method JRequest::getVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/components/com_content/controller.php on line 47

Deprecated: Non-static method JRequest::_cleanVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 134

Deprecated: Non-static method JFilterInput::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 577

Deprecated: preg_replace(): The /e modifier is deprecated, use preg_replace_callback instead in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/filter/filterinput.php on line 512

Deprecated: preg_replace(): The /e modifier is deprecated, use preg_replace_callback instead in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/filter/filterinput.php on line 514

Deprecated: Non-static method JRequest::getVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/components/com_content/controller.php on line 48

Deprecated: Non-static method JRequest::_cleanVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 151

Deprecated: Non-static method JFilterInput::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 577

Deprecated: Non-static method JFactory::getDocument() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/component/controller.php on line 287

Deprecated: Non-static method JRequest::getCmd() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/component/controller.php on line 290

Deprecated: Non-static method JRequest::getVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 255

Deprecated: Non-static method JRequest::_cleanVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 134

Deprecated: Non-static method JFilterInput::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 577

Deprecated: Non-static method JRequest::getCmd() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/component/controller.php on line 291

Deprecated: Non-static method JRequest::getVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 255

Deprecated: Non-static method JRequest::_cleanVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 151

Deprecated: Non-static method JFilterInput::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 577

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JPath::find() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/component/controller.php on line 627

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JMenu::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 705

Deprecated: Non-static method JError::isError() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 706

Deprecated: Non-static method JFactory::getDBO() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/application.php on line 300

Deprecated: Non-static method JRequest::getCmd() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/application.php on line 310

Deprecated: Non-static method JRequest::getVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 255

Deprecated: Non-static method JRequest::_cleanVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 151

Deprecated: Non-static method JFilterInput::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 577

Deprecated: Non-static method JFilterInput::clean() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/application.php on line 311

Deprecated: Non-static method JURI::base() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/component/view.php on line 178

Deprecated: Non-static method JHTML::addIncludePath() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/components/com_content/view.php on line 13

Deprecated: Non-static method JPath::clean() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/html/html.php on line 326

Deprecated: Non-static method JModel::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/component/controller.php on line 592

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JPath::find() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/component/model.php on line 112

Deprecated: Non-static method JModel::addIncludePath() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/component/model.php on line 113

Deprecated: Non-static method JModel::_createFileName() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/component/model.php on line 114

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JFactory::getDBO() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/component/model.php on line 83

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JTable::addIncludePath() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/component/model.php on line 268

Deprecated: Non-static method JRequest::getVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/components/com_content/models/article.php on line 45

Deprecated: Non-static method JRequest::_cleanVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 134

Deprecated: Non-static method JFilterInput::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 577

Deprecated: Non-static method JFactory::getApplication() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/component/controller.php on line 356

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JMenu::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 705

Deprecated: Non-static method JError::isError() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 706

Deprecated: Non-static method JRegistryFormat::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/registry/registry.php on line 373

Deprecated: Non-static method JFilterInput::clean() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/registry/format.php on line 45

Deprecated: Non-static method JFactory::getCache() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/component/controller.php on line 307

Deprecated: Non-static method JFactory::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 192

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JCache::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 208

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Strict Standards: Declaration of JCacheView::get() should be compatible with JCache::get($id, $group = NULL) in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/cache/handler/view.php on line 150

Deprecated: Non-static method JRequest::getCmd() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/cache/cache.php on line 87

Deprecated: Non-static method JRequest::getVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 255

Deprecated: Non-static method JRequest::_cleanVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 151

Deprecated: Non-static method JFilterInput::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 577

Deprecated: Non-static method JRequest::getURI() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/cache/handler/view.php on line 148

Deprecated: Non-static method JFactory::getURI() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 51

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JURI::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 403

Deprecated: Non-static method JCacheStorage::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/cache/cache.php on line 313

Deprecated: Non-static method JFactory::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/cache/storage/file.php on line 37

Deprecated: Non-static method JError::isError() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/cache/cache.php on line 206

Deprecated: Non-static method JFactory::getDocument() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/cache/handler/view.php on line 85

Deprecated: Non-static method JFactory::getUser() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/components/com_content/views/article/view.html.php on line 33

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JFactory::getSession() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 163

Deprecated: Non-static method JFactory::getDocument() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/components/com_content/views/article/view.html.php on line 34

Deprecated: Non-static method JDispatcher::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/components/com_content/views/article/view.html.php on line 35

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Deprecated: Non-static method JPathway::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 682

Deprecated: Non-static method JApplicationHelper::getClientInfo() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/pathway.php on line 75

Deprecated: Non-static method JSite::getMenu() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/pathway.php on line 34

Deprecated: Non-static method JApplication::getMenu() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/application.php on line 345

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JMenu::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 705

Deprecated: Non-static method JError::isError() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 706

Deprecated: Non-static method JError::isError() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 683

Deprecated: Non-static method JComponentHelper::getParams() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/application.php on line 240

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JMenu::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 705

Deprecated: Non-static method JError::isError() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 706

Deprecated: Non-static method JFactory::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 382

Deprecated: Non-static method JFactory::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 382

Deprecated: Non-static method JRegistryFormat::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/registry/registry.php on line 373

Deprecated: Non-static method JFilterInput::clean() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/registry/format.php on line 45

Deprecated: Non-static method ContentHelperQuery::buildVotingQuery() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/components/com_content/models/article.php on line 526

Deprecated: Non-static method JFactory::getUser() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/components/com_content/models/article.php on line 608

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JFactory::getSession() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 163

Deprecated: Non-static method JFactory::getDate() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/components/com_content/models/article.php on line 611

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Deprecated: Non-static method JFactory::getLanguage() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 427

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Deprecated: Non-static method JFactory::getACL() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/user/user.php on line 260

Deprecated: Non-static method JFactory::_createACL() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 227

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 71

Deprecated: Non-static method JFactory::getDBO() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 527

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Deprecated: Non-static method JText::_() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/components/com_content/models/article.php on line 550

Deprecated: Non-static method JFactory::getLanguage() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/methods.php on line 120

Deprecated: Non-static method JFactory::getUser() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/components/com_content/models/article.php on line 110

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JFactory::getSession() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/factory.php on line 163

Deprecated: Non-static method JRegistryFormat::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/registry/registry.php on line 373

Deprecated: Non-static method JFilterInput::clean() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/registry/format.php on line 45

Deprecated: Non-static method JRequest::getVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/components/com_content/models/article.php on line 583

Deprecated: Non-static method JRequest::_cleanVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 151

Deprecated: Non-static method JFilterInput::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 577

Deprecated: Non-static method JRequest::getVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/components/com_content/views/article/view.html.php on line 60

Deprecated: Non-static method JRequest::_cleanVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 151

Deprecated: Non-static method JFilterInput::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 577

Deprecated: Non-static method JTable::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/components/com_content/models/article.php on line 181

Strict Standards: Non-static method JLoader::load() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 161

Strict Standards: Non-static method JLoader::register() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 138

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JPath::find() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/database/table.php on line 91

Deprecated: Non-static method JTable::addIncludePath() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/database/table.php on line 91

Deprecated: Non-static method JFactory::getDBO() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/database/table.php on line 112

Deprecated: Non-static method JFactory::getACL() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/user/user.php on line 260

Deprecated: Non-static method JFactory::getACL() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/user/user.php on line 260

Deprecated: Non-static method JFactory::getACL() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/user/user.php on line 260

Deprecated: Non-static method JRoute::_() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/components/com_content/views/article/view.html.php on line 78

Deprecated: Non-static method ContentHelperRoute::getArticleRoute() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/components/com_content/views/article/view.html.php on line 78

Deprecated: Non-static method ContentHelperRoute::_findItem() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/components/com_content/helpers/route.php on line 49

Deprecated: Non-static method JComponentHelper::getComponent() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/components/com_content/helpers/route.php on line 97

Deprecated: Non-static method JComponentHelper::_load() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/component/helper.php on line 39

Deprecated: Non-static method JApplication::getMenu() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/components/com_content/helpers/route.php on line 99

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JMenu::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 705

Deprecated: Non-static method JError::isError() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 706

Deprecated: Non-static method JFactory::getApplication() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/methods.php on line 41

Deprecated: Non-static method JFactory::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/application.php on line 372

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JRouter::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 659

Deprecated: Non-static method JError::isError() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 660

Deprecated: Non-static method JSite::getMenu() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/router.php on line 419

Deprecated: Non-static method JApplication::getMenu() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/application.php on line 345

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JMenu::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 705

Deprecated: Non-static method JError::isError() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 706

Deprecated: Non-static method JFactory::getApplication() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/router.php on line 401

Deprecated: Non-static method JSite::getMenu() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/router.php on line 295

Deprecated: Non-static method JApplication::getMenu() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/application.php on line 345

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JMenu::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 705

Deprecated: Non-static method JError::isError() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 706

Strict Standards: Non-static method JSite::getMenu() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/components/com_content/router.php on line 19

Strict Standards: Non-static method JApplication::getMenu() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/includes/application.php on line 345

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JMenu::getInstance() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 705

Strict Standards: Non-static method JError::isError() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 706

Deprecated: Non-static method JFactory::getApplication() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/router.php on line 90

Deprecated: Non-static method JFactory::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 382

Deprecated: Non-static method JFactory::getConfig() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/application/application.php on line 382

Deprecated: Non-static method JURI::base() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/includes/router.php on line 109

Deprecated: Non-static method JPluginHelper::importPlugin() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/components/com_content/views/article/view.html.php on line 101

Deprecated: Non-static method JPluginHelper::_load() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 92

Deprecated: Non-static method JPluginHelper::_import() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 97

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Strict Standards: Non-static method JLoader::import() should not be called statically in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/loader.php on line 186

Deprecated: Non-static method JDispatcher::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 140

Deprecated: Non-static method JPluginHelper::getPlugin() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 147

Deprecated: Non-static method JPluginHelper::_load() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 41

Deprecated: Non-static method JRegistryFormat::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/registry/registry.php on line 373

Deprecated: Non-static method JFilterInput::clean() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/registry/format.php on line 45

Deprecated: Non-static method JPluginHelper::getPlugin() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/plugins/content/mavikthumbnails.php on line 118

Deprecated: Non-static method JPluginHelper::_load() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/plugin/helper.php on line 41

Deprecated: Non-static method JRegistryFormat::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/registry/registry.php on line 373

Deprecated: Non-static method JFilterInput::clean() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/registry/format.php on line 45

Deprecated: Non-static method JRequest::getVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/plugins/content/mavikthumbnails.php on line 131

Deprecated: Non-static method JRequest::_cleanVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 134

Deprecated: Non-static method JFilterInput::getInstance() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/environment/request.php on line 577

Deprecated: preg_replace(): The /e modifier is deprecated, use preg_replace_callback instead in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/filter/filterinput.php on line 512

Deprecated: preg_replace(): The /e modifier is deprecated, use preg_replace_callback instead in /home2/sirdik/public_html/fbmi.sirdik.org/libraries/joomla/filter/filterinput.php on line 514

Deprecated: Non-static method JRequest::getVar() should not be called statically, assuming $this from incompatible context in /home2/sirdik/public_html/fbmi.sirdik.org/plugins/content/mavikthumbnails.php on line 132

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10.4.1 Radioprotektiva s krátkodobým účinkem

Mezi látky s krátkodobým účinkem řadíme:

 

Radioprotektivní látky obsahující síru

Radioprotektiv obsahujících síru je celá řada. Mezi nejvýznamnější z hlediska radioprotektivních účinků řadíme:

  • cystamin a cysteamin (aminothioly);
  • aminoetylizotiouronium (AET, derivát thiomočoviny);
  • amifostin (WR 2721) a cystafos (deriváty kyseli­ny thiofosforečné);
  • citrifos a adeturon (sloučeniny cysteaminu a AET s adenosintrifosfátem);
  • merkaptopropionylglycin.

Mechanizmus jejich účinku je dán inaktivací kyslíkových radikálů vznikajících při radiolýze vody -SH skupinou.

 

AmifostinCystaminCysteaminCysteinThiomočovina

 

Již v roce 1949 byl popsán radioprotektivní účinek aminokyseliny cysteinu Pattem a jeho spolupracovníky. V roce 1951 objevila belgická skupina pod vedením Bacqa radioprotektivní účinky cysteaminu (merkaptoetylaminu) a cystaminu (dimerkaptoetylaminu).

 

HS - CH2 - CH2 - NH2

cysteamin

NH2 - (CH2)2 - S - S - (CH2)2 - NH2

cystamin

 

Za nejúčinnější preparát je považována látka označována kódem WR 2721 (podle Walter Reed Institute of Research, USA), která byla produktem rozsáhlého výzkumu zahájeného v roce 1959. V rámci tohoto programu bylo v letech 1959 až 1965 syntetizováno a testo­váno na 4 000 látek. Jedná se o S - 2 (3 - aminopropylamino) etylester kyseliny thiofosforečné, chemicky

H2N - (CH2)3 - NH - CH2 - NH - (CH2)2 - S - PO3H 2.

Radioprotektivní účinek WR 2721 byl prvně popsán v roce 1969. Preparát WR 2721 je znám v odborné literatuře pod různým názvem, nejčastěji v anglosaském názvosloví jako amifostine, v české literatuře jako amifostin (dříve gamafos, označení používané hlavně ruskými radiobiology).

 

S ohledem na výše uvedené řádky se proto zaměříme v dalším textu na možné praktické využití amifostinu a jeho metabolitů. Cytoprotektivní účinek amifostinu je dán především intracelulární koncentrací aktivního metabolitu WR-1065. Ami­fostin sám nevstupuje do buněk s ohledem na koncovou část jeho molekuly, která je tvořena kyselou fosfothiolovou skupinou. Při enzymatické aktivaci ale dochází pomo­cí alkalické fosfatázy k defosforylaci v oblasti této skupiny. Vzniklý defosforylovaný thiol WR-1065 již snadno pomocí pasivní difúze proniká do buněk. Právě potřeba enzymatické aktivace odpovídá za specificitu cytoprotektivního účinku amifostinu. Alkalická fosfatáza je, jako membránově vázaný enzym, přítomná ve vyso­ké koncentraci ve zdravých tkáních, především v endotelu krevních kapilár. Rovněž pH zdravých buněk a tkání je z hle­diska optimální aktivity alkalické fosfatázy příznivé. Naopak nízká vaskularizace, hypoxie a nižší pH v nádorových tkáních neumožňují dostatečnou přeměnu amifostinu na jeho aktivní metabolity a jejich následný vstup do nádorových buněk, proto je také využíván v radioterapii. WR-1065 prostřednictvím volné sulfhydrylové skupiny (SH) rovněž působí v místech poškození DNA, kdy usnadňuje rych­lou neenzymatickou reparaci poškození. Specifický transportní protein zajišťuje cílený transport WR-1065 na ta důležitá mís­ta v jaderném chromatinu, která jsou rozhodující pro udržení integrity DNA a která je proto důležité chránit před účinkem.

 

Amifostin rozpuštěný ve vodě a podaný parenterálně se vstře­bává poměrně rychle. Z plazmy je pravděpodobně eliminován rychlou konverzí na WR-1065, tato eliminace je však saturačně omezená. Vstup amifostinu do různých tkání je odlišný. Největší nahromadění jeho aktivity bylo zjištěno v kostní dřeni, slinných žlázách, střevní sliz­nici, játrech a v kůži, což koreluje s radioprotekcí v těchto tkáních. U těchto tkání se koncentrace látky zvyšuje po aplikaci rychle. Pomalé zvyšování koncentrace bylo zaznamenáno v srdci. Nízká akumulace byla stanovena v kosterním svalu, periferní krvi a prakticky žádná aktivita nebyla zaznamenána v mozku.

WR-1065 je dále přeměněna intracelulárními redoxními reakcemi na disulfidickou sloučeninu WR-33278. WR-33278 se akumuluje především v jádře, kde se váže na nukleární proteiny a DNA a pravděpodobně se účastní řady intracelulárních pochodů, které mají vliv na stabilizaci chromatinu, syntézu DNA, aktivitu kinázových enzymů, expresi genů a tvorbu terciální a kvartérní struktury proteinů.

Amifostin je účinné radioprotektivum s preferencí pro nor­mální tkáně, především slinné žlázy, sliznice a kostní dřeň, kte­ré zabraňuje toxickým účinkům vyvolaným radioterapií, ale i che­moterapií, proto našel uplatnění také v klinické praxi. Amifostin selektivně chrání normální buňky, kdežto tumorózní ne. Radioprotektivní látka WR 2721 byla podrobně zkoumána v minulých létech na radiobiologickém pracovišti Vojenské lékařské akademie Jana Evangelisty Purkyně v Hradci Králové (dnes Fakulta vojenského zdravotnictví Univerzity obrany), kde výzkum této látky pokračuje do současnosti. Československo bylo jednou z mála zemí světa, která dokázala v chemických laboratořích VOZ Zemianské Kostoĺany (dnes Slovenská republika) pod vedením Ing. Cyrila Krajčoviče a prof. MUDr. Pavla Kuny, DrSc. tuto látku syntetizovat již koncem 70. let.

Po intramuskulární aplikaci amifostinu je ochranné účinnosti dosaženo během 15 až 30 minut, zatímco po podání per os je nástup účinku za podstat­ně delší dobu a stupeň poskytované ochrany je nižší. K dosa­žení srovnatelného účinku je pro per os podání nutné zvýšit dáv­ku přibližně třikrát a s ohledem na toxicitu je toto podání proto nevhodné. Doporučené dávkování amifostinu je nyní 2 mg/kg při intravenózním podání s DRF až 2,3. Výhodou injekčního podávání je možnost aplikace inaktivní formy, která po následné aktivaci alkalickou fosfatázou, přítomnou ve vysokých koncentracích v kapilárách a na povrchu buněk, probíhá extracelulárně a následně se aktivní forma dostává do nitra buněk pasivní difúzí.

Nežádoucími účinky podávání amifostinu jsou nauzea, vomitus a hypotenze.

Účinnost amifostinu při ochraně normálních tkání před radia­čním poškozením při radioterapii byla sledována v řadě stu­dií a následně vedla k jeho klinickému využití. Pro klinické studie je amifostin dodáván americkou firmou Shering - Plough pod názvem Ethyol inj. sicc.. V jedné lahvičce je 500 mg amifostinum suché substance. Využívá se nejvíce při radioterapii karcinomů v oblasti hlavy a krku s ohledem na jeho radioprotektivní účinek vzhledem ke slinným žlázám. Možnost aplikace je limitována jak toxicitou, tak i cenou preparátu.

Jako radioprotektivum byl rovněž testován dihydrochlorid cystaminu (sovětské provenience) v tabletové formě obsahoval 0,2 g, později 0,4 g účinné látky. Pro jednorázové podání byla doporučována dávka 0,8 -1,2 g cystaminu přibližně 30 minut před předpokládaným ozařováním. Odhad DRF v oblasti postradiačního poškození krvetvorby u lidí byl 1,2. Nepříliš vysoká hodnota DRF a řada vedlejších účinků takto podávaného cystaminu (nauzea,zvracení, hypotenze, bradykardie) byl důvodem hledání jiného vhodného radioprotektiva.

 

Indolylalkylaminy

 

Indolylalkylaminy způsobují hypoxémii cestou vazokonstrikce. Navozením hypoxie snížíme množství kyslíku ve tkáních a následně i tvorbu kyslíkových radikálů v ozářených tkáních. V souvislosti s tímto mechanizmem byly testovány vybrané vasoaktivní látky. V tomto směru byly rozsáhlé studie věnovány především indolylalkylaminovým derivátům serotoninu (5-hydroxytryptaminu) a mexaminu (5-metoxytryptaminu). Jejich radioprotektivní účinek je vyvolán v savčím organizmu vasokonstrikční hypoxií v důsledku přímého účinku indolylalkylaminů na receptory buněk cévních stěn. Poněvadž byl popsán radioprotektivní účinek indolylalkylaminů i v pokusech s buňkami in vitro, lze uvažovat o jisté buněčné komponentě v mechanizmu jejich ochranného efektu. Tímto mechanizmem je možné dosáhnout DRF až 1,5. Nežádoucí se jeví hypoxické poškození periferních tkání, jako je tomu u varlat.

 

Serotonin

Serotonin.

 

Mexamin

Mexamin.


Ve snaze zvýšit radiorezistenci savčího organizmu byly v experimentu zkoumány ochranné účinky kombinací radioprotektiv, především aminothiolů a indolylalkylaminů nebo cystaminu a mexaminu. Přesto, že byly analyzovány nejrůznější dvou i vícesložkové kombinace radioprotektivních látek, nepodařilo se touto cestou dosáhnout praktického použití u osob ohrožených akutním zevním ozářením. Jako nejúčinnější se ukázala kombinace fyzikálního stínění a radioprotektiva a to zejména neutronového záření.

 

Blokátory vápníkového kanálu

 

Mechanizmu navození intracelulární hypoxie využívá skupina látek označovaná jako blokátory vápníkového kanálu. Významným zástupcem je nifedipin s DRF přibližně 1,3. Avšak efektivní jsou opět dávky blížící se dávkám toxickým.

 

Nifedipin

Nifedipin.

 
 

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